Proteomic and phosphoproteomic profiling linked plectin-dependent disruption of cytoskeletal networks to attenuation of oncogenic FAK, MAPK/Erk, and PI3K/Akt signatures. Importantly, by combining cell ...

Instead of a stick, spray, or roll-on, AKT balm is a cream formula that you apply with your fingers. You’ll need only a pea-sized amount. It can be used on the armpits but also anywhere else you ...

Clearly, the role of estrogen in cardiovascular disease (CVD) is complex, and further study is necessary. More significantly, it seems unlikely that the male/female dimorphisms in CVD can be ...

Bitcoin rebounded 8% from its overnight low as some investors bought its dip below $79,000, although the largest crypto by market value looked wobbly, along with other risk-on assets, after U.S. and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. m 6 A RNA modification has been linked to ...

AstraZeneca has advanced its push to make camizestrant a blockbuster, reporting a phase 3 win for the oral SERD at an interim analysis. The trial hit on progression-free survival (PFS), its ...

PIP3 recruits AKT to the cell membrane, where AKT is activated through phosphorylation by PDK1 at T308 and by mTORC2 at S473. Activated AKT phosphorylates TSC1/2 and relieves its inhibition ...

When a covert mission to rescue a kidnapped CIA operative uncovers a chilling plot, an elite, highly trained U.S. SEAL team speeds to hotspots around the globe, racing against the clock to stop a ...

Ruptured micronuclei do not activate STING signalling. Although several transcriptional reporters of cascades downstream of STING have been used in the past, including the INFb-Luciferase reporter, ...

Bioluminescence (the light produced by fireflies, for instance) requires a chemical reaction involving the molecules luciferin and luciferase. Biofluorescent creatures generate their glow with ...

Bitcoin financial services company Fold began trading publicly on the Nasdaq Composite on Wednesday, joining a small group of crypto-focused companies that are selling shares on major U.S. stock ...