Liver injury is an independent risk factor for multiple organ dysfunction and high mortality in patients with sepsis. However, the pathological mechanisms and therapeutic strategies for ...

Bryan Johnson, the anti-aging influencer, halted his Rapamycin regimen after five years due to adverse side effects like ...

The biomarker analysis found patients with certain mutations in the PI3K/AKT/mTOR pathway and MAPK pathway may be resistant to Truqap.

Can the key to a longer, healthier life be found in your kitchen? As the global population ages, scientists have uncovered ...

Estela Jacinto, a professor of biochemistry and molecular biology at Rutgers Robert Wood Johnson Medical School, has been ...

WAYNE, PA — Palvella Therapeutics, Inc. (Nasdaq: PVLA), a biopharmaceutical company focused on developing treatments for rare ...

Blagosklonny goes on to write that even though rapamycin may reverse some manifestations of aging, it is more effective at ...

Microcystic LMs are a rare, chronically debilitating genetic disease caused by dysregulation of the phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway. The disease is ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu 611137, China School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Key Laboratory of ...

Figure 11. Proposed mechanism of DSF against renal fibrosis via inhibition of PIK3/Akt/mTOR signaling pathway. TGF-β activates the PI3K pathway, leading to the activation of Akt. Activated Akt then ...

The Chinese team’s advance was made possible by implanting electrode chips in the brain and spinal cord to create a bridge or “neural bypass” – thus reconnecting the body’s own pathways.