MTOR Pathway and Roles of G3BP1 and TSC2 The MTOR signaling ... MTORC1 regulation occurs at the lysosome, and is inhibited by TSC2 via an intermediate protein, Rheb. G3BP1, on the other hand, is known ...

Furthermore, lysosome-targeted therapies have shown promise in hematological malignancies, particularly leukemia, where they induce cytotoxic effects on leukemia cells (Table 1). In T-ALL cells, ...

This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence ... via a ROS-Ca 2+-calcineurin dependent but ...

These two amino acids, methionine and leucine, are known activators of a signaling molecule called mTOR (short for "mammalian target of rapamycin"). Leptin-sensitive animals showed no such ...

Advances in multi-omics, artificial intelligence (AI), deep learning (DL), ageing biomarkers, precision imaging, ageing clocks, robotics, and smart technologies have enabled researchers to ...

Cellular targets are located in the cytoplasmic membrane, cytoskeleton, mitochondria, proteasomes, lysosomes and nuclei, and specific signaling pathways are rapidly activated, first by ...

When renal cell cancer is “metastatic,” that means it has spread from your kidney to other parts of your body. Bones are a common place for this cancer to travel. It's harder to treat the ...

β-GC hydrolyzes glucosylceramide (GluCer) into glucose and ceramide in the lysosome, and the loss of its activity leads to GluCer accumulation in different tissues. In severe cases, enzymatic ...