A new study reveals a possible protein misfolding mechanism that may resolve a long-standing mystery of why certain proteins ...

Proteins are long molecules that must fold into complex three-dimensional structures to perform their cellular functions.

To maintain homeostasis, intestinal epithelial cells (IECs) must efficiently manage protein production and secretion, a ...

Subscribe for FREE “For most proteins, we model the folding process as if there are two states, folded or unfolded,” said Yang Jiang, assistant research professor of chemistry in the Eberly College of ...

The protein folding machinery of the endoplasmic reticulum is coupled to the burden of unfolded proteins by an unfolded protein response (UPR) that promotes rectifying transcriptional and ...

successfully visualized how the SecYEG-SecA complex helps mediate the translocation of unfolded proteins across the bacterial membrane at a molecular level. Real-time dynamics of protein ...

In 1972, Christian Anfinsen shared a Nobel Prize in Chemistry for research from the 1950s showing that the linear sequence of the amino acids of a protein contains the information the molecule needs ...

As the team listened to the hydrogen bonds breaking and forming as the protein folded and unfolded, they picked up on patterns in the noise. “It’s like listening to a symphony orchestra where a lot of ...