"Insulin binding to InsRα derepresses the tyrosine kinase activity of the β-subunit (InsRβ). This initiates a whole metabolic pathway with different steps that eventually allow glucose ...

(IGF1, insulin-like growth factor 1; MAPKAP-K1, mitogen-activated protein kinase (MAPK)-activated protein kinase 1; PDK1, 3-phosphoinositide-dependent protein kinase 1; PKB/AKT, protein kinase B ...

The phosphoinositide 3-kinase (PI3K) pathway is a crucial signal transduction system linking the activation of receptor tyrosine kinases (RTKs), G protein-coupled receptors (GPCRs) and oncogenes ...

The molecular basis of phospho-tyrosyl-regulation of Src-family and Syk-family protein tyrosine kinases in signaling pathways is a current focus of the lab. The conformational activation of Src kinase ...

More information: A 3-week pause versus continued Bruton tyrosine kinase inhibitor use during COVID-19 vaccination in individuals with chronic lymphocytic leukaemia (IMPROVE trial): a randomised, open ...