Cells from the telomerase knockout mouse immortalize with ... of this difference between mice and men and its relationship to cancer. The evidence supporting the relevance of replicative ...

Unicellular organisms, human cells and mice have provided ... has been aided by genetically defined cancer-prone mice that lack telomerase activity. These mouse models have provided insights ...

In contrast to human somatic cells that are telomerase negative, telomerase activity is typically ... 8 The observed association between shorter telomeres and increased risk of cancer, cardiovascular ...

Those that are too long predispose to cancer, and those that are too short lose their protective ability, resulting in ...

The laboratory is using or has plans to use many cutting-edge technological developments in cancer and aging genetics and translational research such as RRBS-seq and Single-cell epigenomics. Studies ...

Over time, they become less and less able to fight infection, cancer, and disease ... Previously, scientists knew that T cells employ telomerase, an enzyme that extends telomeres, to combat telomere ...

The research team found that a small molecule, SP2509, can block the reactivation of telomerase in cancer cells by inhibiting iron's interaction with the enzyme. In laboratory tests using cancer ...

Cell aging has always been an important topic in biological research, and telomere shortening is one of the key issues in cell aging studies.

MAIA’s second generation research and discovery platform seeks to identify new telomere-targeting THIO-like compounds with potentially improved specificity towards cancer cells relative to ...

Monitor complete blood cell counts prior to initiation ... to change lives by changing the course of blood cancer. Our first-in-class telomerase inhibitor RYTELO™ (imetelstat) is approved ...