Huntington's disease is a rare genetic, autosomal dominant, neurodegenerative disease, caused by CAG repeat expansions in the HTT gene, that is polymorphic on the healthy allele and contains more than ...

Knocking it down with an antisense oligonucleotide blocked CAG expansion in HD neurons. The ASO also took down MSH3 in the brains of human MSH3 knock-in mice. In stem-cell-derived striatal neurons ...

Although most cells showed modest somatic expansions, the longest expansions — some of which exceeded 800 repeats — were found exclusively in medium spiny neurons (also called striatal ...

This study uncovers a specialized circuit in the striatum that encodes reward variance, offering new perspectives on learning and neurological disorders.

Together, these neurons grant the brain the capacity to assess the entire ... “We used high-density probes (neuropixels) to record striatal activity from mice performing a classical conditioning task ...

The songbird vocal motor nucleus HVC contains cells that project to the basal ganglia, the auditory system, or downstream vocal motor structures. In this fundamental study, the authors conduct ...

Get Instant Summarized Text (Gist) Chronic stress alters brain activity between two amygdala-striatal pathways, impairing flexible decision-making and promoting rigid habits. The basolateral ...

Coronary artery disease (CAD), or the narrowing of the coronary arteries, is the leading cause of morbidity and mortality throughout the world. Atherosclerosis, or the buildup of plaque in the ...

From this data, she gleaned that, of the three groups, the one that had the lowest striatal dopamine levels also performed worse in inhibitory control. Parr speculated. “These individuals might be ...