Huntington's disease is a rare genetic, autosomal dominant, neurodegenerative disease, caused by CAG repeat expansions in the HTT gene, that is polymorphic on the healthy allele and contains more than ...

Although most cells showed modest somatic expansions, the longest expansions — some of which exceeded 800 repeats — were found exclusively in medium spiny neurons (also called striatal ...

Striatonigral neurons comprise diverse subtypes ... and that this is related to blunted striatal reward response following D2/D3 antagonism.

Impact and progress Frontiers' impact Progress Report 2022 All annual reports ...