They include the dysregulation of the expression of thousands of genes in the striatal neurons and an accumulation of clumps of mutant Huntingtin protein (called aggregates), which are a hallmark ...

Distinct populations of striatal neurons were found to represent different parts of the reward distribution, with D1 neurons encoding the upper range consisting of optimistic predictions ...

Huntington's disease is a rare genetic, autosomal dominant, neurodegenerative disease, caused by CAG repeat expansions in the ...

Knocking it down with an antisense oligonucleotide blocked CAG expansion in HD neurons. The ASO also took down MSH3 in the brains of human MSH3 knock-in mice. In stem-cell-derived striatal neurons ...

Within striatal neurons that subserve dopaminergic regulation of reward processes, D1-receptor signaling cascades can be heterogeneously distributed along cell bodies and dendrites, and A-kinase ...