Figure 1: The Sonic hedgehog (Shh ... a genetically engineered mouse model of pancreatic cancer to demonstrate that inhibiting the hedgehog pathway in stroma cells—with Infinity's small molecule ...

The Hedgehog (Hh) pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. The first and often genetically ...

In a study published in PLOS Biology, researchers blocked a developmental pathway called “sonic hedgehog” (named after the video game character) in chicken embryos. This caused the chickens to ...

Alteration of the expression of the co-called 'Sonic Hedgehog' gene can transform feet scale and wing feathers. While a transient over-expression of the gene can permanently turn feet scales into ...

We have also conducted an immunohistochemical study for expression of PTCH1 and SMO in a large panel of normal, ductal carcinomas in situ (DCIS), and invasive breast cancer (IBC ... these data suggest ...