Four different human cancer cell lines were cultured to carry out this study: the colorectal adenocarcinoma (COAD) SW620 cell line, the pancreatic adenocarcinoma (PAAD) BxPC-3 cell line, the prostatic ...

The HCT116 cell line was obtained on 13 May 2023 and tested by STR. Other colorectal cell lines (RKO, HCT15, SW480, SW620, DLD-1) were obtained from ATCC. The RKO cell line was grown in RPMI-1640 ...

This manuscript reports important findings that the methyltransferase METTL3 is involved in the repair of abasic sites and uracil in DNA, mediating resistance to floxuridine-driven cytotoxicity. The ...

Objective Dysregulated cellular metabolism is a distinct hallmark of human colorectal cancer (CRC). However, metabolic programme rewiring during tumour progression has yet to be fully understood.

This study provides important insights into the regulation of type-I interferon signaling and anti-tumor immunity, demonstrating that ORMDL3 promotes RIG-I degradation to suppress immune responses.