The ERBB receptors are a group of receptor tyrosine kinases (RTKs) involved in key cellular functions including cell growth and survival. What are the activation mechanisms particular to ERBBs?

Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid mediators exert their effects by activating two G protein-coupled receptors, ...

Within cell membranes, ion channel receptors typically activate in response to electrical, chemical or other specific stimuli ...

In addition to regulation of subcellular location, ERBB receptors are also regulated in ways that affect their signaling activity. Ultimately, the maturation, dimerization, activation, time of ...

"What we found was that the chemicals were not able to activate the mosquito wasabi receptor as effectively when temperatures exceeded the heat activation threshold," said Piermarini. "So the ...

What we discovered is that ibuprofen and naproxen inhibit activation of the sweet taste receptor in people, as well as in human cells. We determined that if ibuprofen and naproxen inhibit sweet ...