Among other variations, there was a Python Elite Stainless made from 1997 to 1999, then again from 2002 to 2006. The end of the production Python was caused, oddly enough, by its quality.

One of seven mid-20th century Colt handguns named after snakes, the Python was introduced in 1955. The Python was a beefy, all steel and wood revolver chambered in .357 Magnum.

The front sight is interchangeable and has a Red-Ramp face on the visible side, which allows the revolver to be zeroed with both full power .357 Mag. loads or softer .38 Spl. loads.

One of seven mid-20th century Colt handguns named after snakes, the Python was introduced in 1955. The Python was a beefy, all steel and wood revolver chambered in .357 Magnum.