Here, we explored how NMDARs signal in tLTD. We found that, regardless of frequency, L5 PC→PC tLTD relies on the non-ionotropic preNMDAR signaling pathway mediated by JNK2, which helps to resolve the ...

Insilico Medicine Ltd. has identified postsynaptic density-95 (PSD-95) protein inhibitors acting as neuroprotective agents reported to be useful for the treatment of epilepsy, anxiety disorders, ...

By influencing calcium homeostasis, local protein synthesis and the endoplasmic reticulum, a small protein called Rab10 emerges as a crucial cytoplasmic regulator of neuropeptide secretion.

A research team has established an innovative intracranial pre-olivary pretectal nucleus (OPN) optic tract injury model ...

New structural markers of memory storage uncovered by Scripps Research may pave the way for new treatments for memory loss.

Silent synapses are dormant neural connections that hold untapped brain potential. Discover how ketamine, exercise, and other ...

Research has demonstrated that BDNF binding to a protein known as the TrkB receptor triggers a cascade that promotes the insertion of AMPA receptors into the postsynaptic membrane of silent synapses.

They found more synapses and postsynaptic partners in the brain of Drosophila melanogaster correlating to lower environmental temperature during pupal development. The rate of development of ...