Antimicrobial peptides (AMPs ... Another “in silico” methodology is the molecular docking, a reliable tool able to locate the probable binding interactions of ligands with their target proteins ...

Biomedical engineers at Duke University have developed an AI-based platform that designs short proteins, termed peptides, capable of binding and destroying previously undruggable disease-causing ...

For years, scientists have focused on amyloid beta buildup as the main culprit in Alzheimer’s disease, but a new study suggests the real problem might lie in a stalled protein-cutting process in the ...

Optibrium, a leading developer of software and AI solutions for molecular design today announced the introduction of a new PyMOL Graphical User Interface (GUI) for Surflex-Dock, its industry-leading ...

Protein design (or protein engineering) is a technique by which proteins with enhanced or novel functional properties are created. Proteins can be engineered by rational design, which typically ...

Bacterial infection can be recognized by Toll and IMD pathways, which activate two NF-κB transcription factors, Dorsal and Relish, respectively, to eventually lead to boosting the expression of ...

Collagen is the primary building block of your body's skin, muscles, bones and more. But it's hard to keep the levels in check because as you age, your body's collagen levels naturally decline.

However, experimental determined structures for degradation complexes are scarce. Protein–protein docking can reveal low energy ternary complexes and popular conformational ensembles, providing ...

This study by Wu et al. provides valuable computational insights into PROTAC-related protein complexes, focusing on linker roles, protein-protein interaction stability, and lysine residue ...