Upon activation, p53 transcriptionally upregulates an extensive repertoire of genes including those affecting cell fates such as cell cycle arrest, senescence, and apoptosis. What remains unclear is ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

This important study shows that nutrient stress emanating from the microenvironment induces metabolic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Using a combination of cell-based and ...

During the past 20 years, the advent of neoadjuvant, primary, and adjuvant concurrent chemoradiotherapy has improved cancer care dramatically. Significant contributions have been made by ...

cell cycle, and cell death analysis. Quantitative RT-PCR measured expression of key FAs transporters in Pt-S and Pt-R cells. Immunohistochemistry (IHC) assessed expression of FABP4 in primary and ...