June 19, 2020 — Researchers have developed LIH383, a novel molecule that binds to and blocks a previously unknown opioid receptor in the brain, thereby modulating the levels of opioid peptides ...

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The company previously announced data from another Phase III trial of cebranopadol, which also met its primary endpoint.

Glucagon-like peptide receptor agonists (GLP-1RAs ... Now, these drugs are being investigated for a new and unexpected application: opioid use disorder (OUD). Last month, Eli Lilly CEO Dave ...

The latest readout saw cebranopadol, a dual nociceptin/orphanin FQ peptide (NOP) receptor and µ-opioid peptide (MOP) receptor agonist, tested in a phase 3 trial of patients who have undergone toe ...

About Cebranopadol (TRN-228) Cebranopadol is a first-in-class investigational therapy that targets two key receptors, the nociceptin/orphanin FQ peptide (NOP) and µ-opioid peptide (MOP ...

Cebranopadol – a dual-NMR agonist working on nociceptin/orphanin FQ peptide (NOP) and mu-opioid peptide (MOP) receptors – is a potential first-in-class alternative to opioid analgesics ...

Cebranopadol is an investigational dual-nociceptin/orphanin FQ peptide receptor and µ-opioid peptide receptor (dual-NMR) agonist. The novel therapy is expected to provide pain relief while reducing ...

Mounjaro or Zepbound appear to help people battle alcoholism and opioid addiction, a new study finds. People taking this ...

Purpose. Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP ...