Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

A research team led by Prof. Cao Xiaofeng at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese ...

Single-cell multiomic analyses reveal known and new genes and pathways involved in the development of germ cells and provide a discovery platform for the scientific community.

Chronic hepatitis B virus (HBV) infection continues to pose a major global health threat. The virus evades immune responses and antiviral therapies due to the persistence of covalently closed circular ...

Hepatitis B virus infection remains one of the leading causes of liver disease, including cirrhosis and hepatocellular carcinoma.

Here, cryo-electron tomography (cryo-ET) of PRC1–chromatin condensates reveal randomly oriented neighboring nucleosomes in a stable, open chromatin mesh that might exclude large protein ...

In addition, genes and their regulatory elements need to communicate, and chromatin must open to allow transcription and replication. Important questions are 'how does the linear order of genes ...

First-in-class oral selective SMARCA2 (BRM) inhibitor FHD-909 (LY4050784) continues enrollment in Phase 1 trial for SMARCA4 (BRG1) mutated ...

Despite making up half of the global population, women's health has often been sidelined by traditional health care systems.

NEW YORK - Ludwig Cancer Research extends its congratulations to Ludwig Harvard's Bradley Bernstein on his election as Fellow ...

Scientists discovered a way to block hepatitis B infection using an anticancer drug, offering hope for new treatments.

Researchers from Northwestern University have stumbled upon a previously unobserved function of a protein found in the cell ...