Natural nucleic acids like DNA and RNA have a sugar-phosphate "backbone" and nitrogen-based components; while the nitrogen-based components in SNA and L- a TNA remain the same, they have an amino ...

Glycol nucleic acid (GNA; shown, B = base)—the analog introduced by Meggers, postdoc Lilu Zhang, and collaborator Adam Peritz—has just three carbon atoms and one stereocenter in the backbone ...

Stephen C. Erfurth, Ernest J. Kiser, Warner L. Peticolas, Determination of the Backbone Structure of Nucleic Acids and Nucleic Acid Oligomers by Laser Raman Scattering, Proceedings of the National ...

While evidence for this RNA-world hypothesis has grown, some scientists have questioned whether nucleic acids with a backbone of ribose, or any other sugar molecule, would be stable enough to ...

Structure and Properties of PNAPeptide nucleic acids (PNAs) are sophisticated oligonucleotide analogs that feature nucleobases, a peptide backbone, as well as an N-terminus and a C-terminus. The ...

Peptide nucleic acids (PNAs) represent a revolutionary class of synthetic nucleic acid analogues, in which the traditional sugar–phosphate backbone is replaced by a neutral N-(2-aminoethyl ...

Peptide nucleic acids (PNAs) are synthetic analogues of natural nucleic acids, distinguished by a peptide‐like backbone that confers unique binding affinities and high stability against ...