Natural nucleic acids like DNA and RNA have a sugar-phosphate "backbone" and nitrogen-based components; while the nitrogen-based components in SNA and L- a TNA remain the same, they have an amino ...

Glycol nucleic acid (GNA; shown, B = base)—the analog introduced by Meggers, postdoc Lilu Zhang, and collaborator Adam Peritz—has just three carbon atoms and one stereocenter in the backbone ...

Natural nucleic acids like DNA and RNA have a sugar-phosphate "backbone" and nitrogen-based components; while the nitrogen-based components in SNA and L- a TNA remain the same, they have an amino ...

Nucleic acids are the backbone of molecular biology research. As such, preservation of their integrity and purity is fundamental for genomic research. Low quality samples can lead to inconsistent ...

Stephen C. Erfurth, Ernest J. Kiser, Warner L. Peticolas, Determination of the Backbone Structure of Nucleic Acids and Nucleic Acid Oligomers by Laser Raman Scattering, Proceedings of the National ...

Peptide nucleic acids (PNAs) represent a revolutionary class of synthetic nucleic acid analogues, in which the traditional sugar–phosphate backbone is replaced by a neutral N-(2-aminoethyl ...

Nucleic acids were first discovered by Friedrich Miescher in 1871. Artificial nucleic acids include peptide nucleic acid (PNA), Morpholino and locked nucleic acid (LNA), as well as glycol nucleic ...

CAMBRIDGE, Mass., April 20, 2023 (GLOBE NEWSWIRE) -- Wave Life Sciences Ltd. (Nasdaq: WVE), a clinical-stage genetic medicines company committed to delivering life-changing treatments for people ...

Wave paper on PN chemistry for silencing in the CNS, and the implications for oligonucleotides more broadly, designated as a Breakthrough Article by Nucleic Acids Research Publications highlight ...

While evidence for this RNA-world hypothesis has grown, some scientists have questioned whether nucleic acids with a backbone of ribose, or any other sugar molecule, would be stable enough to ...

Structure and Properties of PNAPeptide nucleic acids (PNAs) are sophisticated oligonucleotide analogs that feature nucleobases, a peptide backbone, as well as an N-terminus and a C-terminus. The ...

Review Published: 23 November 2015 Nucleic acid targeting: towards personalized therapy for head and neck cancer S M Parsel, J R Grandis & S M Thomas Oncogene 35, 3217–3226 (2016) Cite this article ...