They are the most abundant white blood cell and comprise 50–70% of the population under normal conditions.3 Neutrophils have multi-lobed nuclei generally with 3–5 segments joined by thin strands, ...

Neutrophils secrete granule proteins, such as cathelicidin and cathepsin G. Cathepsin G is released following the activation of neutrophils by platelet-borne CCL5.

Neutrophils, when they encounter signs of infection or inflammation, typically respond initially by releasing, via exocytosis, milder compounds within "gelatinase granules" -- capsule-like ...

Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria. Interleukin 8 (IL-8) activation of ...

On the contrary, gelatinase granules of WASH-deficient neutrophil leukocytes are characterized by decreased Rac1, shortened granule-associated actin comets and impaired exocytosis.

Many of the downregulated genes encoded enzymes involved in degradation and bactericidal processes, within neutrophil granules, or genes that are expressed at high levels on non-lymphocyte white ...

Neutrophils, once considered simple foot soldiers of innate immunity, are now recognized as complex players in cancer.

Nevertheless, in the alternative scenario (granule secretion), only 17% of patients developed CAPA. The team observed that neutrophils efficiently regulated the infection when the intrinsic growth ...

We have investigated the dynamics of exocytosis in single human neutrophils. The increase of membrane area associated with granule fusion was followed by time-resolved patch-clamp capacitance ...

They are the most abundant white blood cell and comprise 50–70% of the population under normal conditions.3 Neutrophils have multi-lobed nuclei generally with 3–5 segments joined by thin strands, ...