Genetic analysis of six subjects revealed an absence of myeloid differentiation primary response 88 (MYD88) or cluster ... of a better response to BTK inhibitors. Sellas Life Sciences CEO and ...

Calcineurin inhibitors are topical and systemic immunosuppressants. They can help treat atopic dermatitis and autoimmune disorders such as lupus and psoriasis. They may also help prevent organ ...

Eighty percent of patients with relapsed or refractory Waldenstrom’s macroglobulinemia responded to treatment with iopofosine I 131, researchers found. A small study of iopofosine I 131 in patients ...

Herpesvirus-encoded microRNAs (v-miRNAs) play a crucial role in modulating host cellular processes to promote viral persistence, immune evasion, and pathogenesis. These v-miRNAs function by targeting ...

Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai 200433, China ...

Baicalein, a potent 12/15-LOX (12/15-lipoxygenase) inhibitor, demonstrates neuroprotective effects by reducing inflammatory lipid mediators, modulating key inflammatory pathways, and attenuating ...

Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R.

Gasdermin forms pores on the membrane promoting pyroptosis and subsequently, inflammation. The NF-κB pathway is activated via MyD88 signaling. TLR4, toll-like receptor 4; NLRP3, NLR family pyrin ...

According to the World Health Organization, cancer is one of the leading global health concerns, causing nearly 10 million deaths in 2020. While classical chemotherapeutics produce strong cytotoxicity ...