The following is a summary of “Novel protein C variant p.C101F results in early intracellular degradation that drives type I ...

Methods Bovine cartilage resorption assays, chondrocyte cell-line SW1353 and primary human articular chondrocytes were used with the general proteasome inhibitor MG132 or vehicle to identify a role of ...

Proteasome inhibitor MG132, lysosome/autophagosome inhibitor chloroquine (CQ) or caspase-3 inhibitor Ac-DEVD-CMK (Sigma-Aldrich) were used at a 20, 50, or 80 μM concentration, respectively, during ...

MG132 and bortezomib are widely used proteasome inhibitors that suppress protein degradation via the proteasome pathway. Different UPS components modulate cellular functions associated with APS ...

EGFR ubiquitination after EGF treatment (50 ng/ml, 10 min) was examined by EGFR IP followed by Ub IB. Cells were pretreated with 20 µM MG132 and 100 nM Bafilomycin A1 for 4 hours. ZNRF3 and RNF43 form ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...

Background Schaaf-Yang syndrome (SYS) is caused by truncating mutations in MAGEL2, mapping to the Prader-Willi region (15q11-q13), with an observed phenotype partially overlapping that of Prader-Willi ...