News Medical on MSN6d
FXR cyclic peptide antagonists as a novel strategy for MASH treatmentIn this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...
Bile acids are natural ligands of FXR, which bind to the ligand-binding pocket (LBP) in the ligand-binding domain (LBD) of FXR, inducing conformational changes that recruit co-activators and ...
Seth Wander, MD, PhD, discusses the significance of ESR1 mutations in patients with hormone receptor–positive, HER2-negative ...
8don MSN
From growth hormones to cancer drugs, small molecules play a crucial role in our health. Monitoring them is essential to ...
K. Sadasivan Pillai Wednesday, March 5, 2025, 08:00 Hrs [IST] ...
Domain Therapeutics ("Domain" or "the Company"), the GPCR experts harnessing deep receptor biology to develop breakthrough treatments for patients, today announces it has nominated and is progressing ...
According to the latest information released by the Fungicide Resistance Action Committee (FRAC), over 30 fungicide selective targets have been identified and acknowledged in the field of fungicide ...
Topline interim dataset from GALAXIES Lung-201 with >240 patients anticipated in 2Q25- Interim datasets from GALAXIES H&N-202 and ...
Quantum-Si aims to revolutionize protein sequencing amidst technological hurdles, uncertain advancements, and market ...
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