Though a complex interplay of genes, diet, and environment contribute, 90% of cases share one thing in common: leptin resistance. In lean individuals, fat cells produce the hormone leptin ...

If this hypothetical factor were carried through the blood, I reasoned, I could test for its presence by ... In humans, many leptin deficiency syndromes are responsive to leptin replacement ...

Researchers say study findings have important implications for our understanding of the pathogenesis of obesity and potential therapeutic applications.