Reference: Tuck JR, Dunlap LE, Khatib YA, et al. Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential. Proc Nat Acad Sci USA. 2025. doi: 10.1073/pnas.2416106122 This ...

The study, “ Molecular design of a therapeutic LSD analogue with reduced hallucinogenic potential,” was authored by Jeremy R. Tuck, Lee E. Dunlap, Yara A. Khatib, Cassandra J. Hatzipantelis ...

Timeline Published: 01 April 2003 Discovering risperidone: the LSD model of psychopathology Francis C. Colpaert Nature Reviews Drug Discovery 2, 315–320 (2003) Cite this article ...

Brain's 'Master Molecule' Produces Same Behavior In Mice From Three Different Psychostimulant Drugs Date: November 24, 2003 Source: Rockefeller University Summary: A mouse study reported in this ...

LSD is one of the most powerful psychedelics ever discovered, so adapting it safely could unlock major therapeutic benefits. The JRT compound proves that tiny changes in molecular structure can ...

Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that ...

How LSD Binds to the Brain, and Why Trips Last So Long Published Jan 26, 2017 at 12:25 PM EST Updated Jan 31, 2017 at 1:16 PM EST ...

In this case, three different drugs of abuse, LSD, PCP ("angel dust") and amphetamine, work on three different neurotransmitters, serotonin, glutamate, and dopamine, respectively.

JRT also did not produce the “head-twitch” response – a widely used indicator of hallucinogenic activity – in mice. When mice were co-treated with LSD, JRT blocked this behavior, suggesting it may ...