RNA splicing is a modification of the nascent pre-messenger RNA (pre-mRNA) transcript in which introns are removed and exons are joined prior to translation. For many eukaryotic introns, splicing ...

HC Bioscience is shutting down after conducting preclinical models for a transfer RNA (tRNA) asset designed to treat hemophilia A. The Cambridge, Massachusetts-based biotech is closing ...

A Boston biotech try­ing to bring trans­fer RNA (tR­NA) bi­ol­o­gy to the drug de­vel­op­ment field has shut­tered op­er­a­tions, End­points News has learned.

Different subsets of the tRNA pool in human cells are expressed in different cellular conditions. The ‘proliferation-tRNAs’ are induced upon normal and cancerous cell division, while the ...

In addition to GCN2 activation and reduced total translation, the reduced charging of tRNA Gln in amino-acid-deprived cells also leads to specific depletion of proteins containing polyglutamine tracts ...