Bone can heal itself, but not always in the ways we expect. Some animals regrow entire limbs. Others, like humans, can only ...

Progenitor cells differentiate into osteoblasts through intramembranous ossification, sequentially rebuilding the bone from the proximal to distal ends. This highly reproducible process provides a ...

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Despite the absence of VEGF, eECMs retained full capacity to instruct ectopic endochondral ossification. Conversely, RUNX2-edited eECMs exhibited impaired hypertrophy, reduced ectopic ossification, ...

The study presents valuable insights into the role of periosteal stem cells in bone marrow regeneration. The evidence is convincing. The data broadly support their claims and in line with state-of-art ...