Nature22y
Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors
The activity of a recombinant insulin receptor tyrosine kinase was measured using Raytide (Calbiochem, La Jolla, CA, USA) as substrate. The conditions for the in vitro kinase assays were as ...
News Medical on MSN3d
Adrenomedullin hormone as key driver of insulin resistance in obesity-linked type 2 diabetes
Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.
High levels of adrenomedullin found to promote obesity-associated insulin resistance
Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...
BioWorld19d
PTP1B allosteric inhibitor enhances glucose uptake in insulin resistance models
Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...