In fact, the more we learn about biochemical pathways that this class of drug ... from a family of chemical messengers called the incretins, which Belgian physiologist Jean LaBarre first purified ...

In fact, the more we learn about biochemical pathways that this class of drug targets ... peptide 1(GLP-1), a hormone from a family of chemical messengers called the incretins, which Belgian ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

Nutrient intake stimulates the secretion of the gastrointestinal incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which exert glucose ...

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...

But still, early findings are a promising signal of quality improvement – a useful benefit of all the pieces of the Quality Pathway working together. If there continue to be significant ...

Hunger is an ancestral and evolutionary survival instinct; its importance is evident in the complex and redundant pathways involving ... endocrine and neurologic signaling that controls energy ...