Hunger is an ancestral and evolutionary survival instinct; its importance is evident in the complex and redundant pathways involving all five senses that regulate it. 1,2 Historically, when humans ...

In humans, this phenomenon is known as the incretin effect,' explains Jan Ache. It suggests that insulin secretion is not simply controlled by the rise in blood sugar levels, but by more complex ...

Incretins are intestinal hormones secreted in response to nutrient entry into the gut, inducing insulin secretion and inhibiting glucagon release. While this response is diminished in individuals with ...

Thus, diet alone may have profound effects on β-cell function and incretin secretion. Considering the findings of these studies, it is evident that incretin hormones play a pivotal role in ...

Semaglutide mimics the action of the natural protein glucagon-like peptide 1(GLP-1), a hormone from a family of chemical messengers called the incretins, which Belgian physiologist Jean LaBarre ...

"This has been an evolution, to discover incretins with more appealing pharmacological properties," he said. "Not all GLP-1s are the same." Retatrutide, the 'King Kong' drug to mimic bariatric ...

The extent to which newer, incretin-based drugs for obesity improve disease outcomes via weight loss versus the direct effects of these drugs is the subject of intense interest. Although reductions in ...

This phenomenon, known as the incretin effect in humans, suggests that insulin secretion is not solely triggered by elevated blood sugar levels. Instead, it involves a more complex interplay of ...

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