The use of high-dose methotrexate (HD-MTX) has improved survival rates. This article describes the experience of a patient treated with HD-MTX and outlines the essential aspects of care for the ...

R2 was a factorial randomization resulting in four arms: high-dose methotrexate (HDM) with pulses, HDM without pulses, standard interim maintenance (SIM) with pulses (standard of care), and SIM ...

Initially 12g/m 2 IV infusion over 4 hours; may be increased to 15g/m 2; see literature for leucovorin rescue dosing with high-dose methotrexate. Be fully familiar with this drug's toxicity before ...

The study included adults ≥18 years old who received high-dose IV methotrexate and developed methotrexate-associated AKI, defined as a ≥1.5-fold increase in serum creatinine within 4 days ...

Patients were receiving concomitant methotrexate, and were randomly allocated ... Reductions in C-reactive protein levels were greatest in the high-dose groups. Doses of 200 mg or higher had ...

Initially 12g/m 2 IV infusion over 4 hours; may be increased to 15g/m 2; see literature for leucovorin rescue dosing with high-dose methotrexate. Be fully familiar with this drug's toxicity before ...