Researchers at the University of Gothenburg have identified a small molecule, PZL-A, that restores function in the defective ...

By binding uniquely to the helicase domain of WRN, IDE275 (GSK959) delivers potent and selective inhibition across MSI-H models," said Michael White, Ph.D., Chief Scientific Officer, IDEAYA ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen interacting with DNA, the laboratories of KAUST Assistant Professor Alfredo De Biasio ...

MOMA Therapeutics, a clinical-stage biopharmaceutical company discovering and developing a new generation of precision ...

For the first time, researchers have filmed in real time the disassembly of DNA at the atomic scale. This strand separation ...

Using cutting edge cryo-electron microscopy, the team of scientists were able to visualise a helicase enzyme (nature's DNA unzipping machine) in the process of unwinding DNA. DNA helicases are ...

However, despite decades of study, many aspects of helicase function remain unclear, including the exact mechanics of strand separation, how ATP hydrolysis drives movement, and how helicases ...

Using cryo-electron microscopy and deep learning to observe the helicase Simian Virus 40 Large Tumor Antigen interacting with DNA, the laboratories of KAUST Assistant Professor Alfredo De Biasio ...