“These findings suggest that AP2A1 expression modulates cell states between senescence and rejuvenation,” the researchers write. To understand how significant this finding is, we need to look at what ...
Sirt1 demonstrates deacetylation effects on PGC-1α, HMGB1, FOXOs, and p53. It hinders the activation of NLRP3 inflammasome and NF-κB while also engaging with AMPK. It regulates inflammatory response, ...
These salutary effects have so far been attributed to isoflavones present in soybeans. Considering cellular senescence contributes to cognitive decline and that no specific soy-derived peptides are ...
Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration.
The authors conclude that PCBP2 is an intrinsic aging factor, the decrease of its expression during aging results in cell proliferation activity decrease and cell senescence. The study provides ...
Mission Statement: Evidence-based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research ...
Our bodies naturally age as cells gradually become less active, transitioning into a state known as senescence. Senescent cells are not just older; they are distinctly larger and characterized by ...
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, China ...