In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...

In the experiments, the mice receive a high-fat diet (HFD) over several weeks and accordingly put on ... specifically those suffering from non-alcoholic fatty liver disease and cirrhosis of the liver.

Moreover, non-alcoholic fatty liver disease was also improved by the treatment ... Notable discoveries include the identification of High-Fat Diet (HFD)-induced CD9+ Trem2+ macrophages and the ...

HFD, high-fat diet; IL-1β, interleukin 1beta; MAFLD, metabolic dysfunction-associated fatty liver disease; MASH, Metabolic dysfunction-associated steatohepatitis; MCP-1, monocyte chemotactic protein 1 ...

The hiker, a woman in her 20s, reported feeling unsafe and unable to descend the trail on her own, according to an HFD news release. HFD personnel reached her at 5:07 p.m., conducted a medical ...

Already a Honolulu Star-Advertiser subscriber? Log in now to continue reading. Takahashi, HFD’s 2024 manager of the year, was lauded by department leadership following his nomination and review ...

WAIPAHU, Hawaii (Island News) – The Honolulu Fire Department (HFD) responded to a reported car fire in the Waipahu Shopping Plaza. The car fire was reported on Saturday, February 15, 2025 ...

Doctors warn, fatty liver can lead to liver cancer if ignored! Here's how to prevent non-alcoholic fatty liver disease. 38% of people have non-alcoholic fatty liver disease. Here’s how to ...

WAIANAE, Hawaii (Island News) – The Honolulu Fire Department (HFD) rescued two hikers from Mount Kaala Trail in Waianae on Friday night, February 21, 2025. HFD responded to the trail at ...