Both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are endogenous physiological substrates for DPP-4, and chemical inhibition of DPP-4 activity ...

In living organisms, protein molecules with different chemical structures called proteoforms, are produced from a single gene ...

Lipidated analogues of glucagon-like peptide ... therapeutic peptides is their physical stability, which greatly influences manufacturing and drug product development. This work provides a systematic ...

BIOHIT is excited to announce an agreement with Biomedal to supply its iVYLISA, iVYCHECK and GlutenDetect gluten immunogenic peptide (GIP) tests. Under this agreement, BIOHIT will have exclusive ...

they form cable-like structures that intertwine like living gels," says Sujit Datta, a professor of chemical engineering, bioengineering, and biophysics at Caltech and corresponding author of the ...

Background: Despite their potential, Glucagon-like peptide-1 receptor agonists (GLP-1 RA) have not been well studied in cardiac amyloidosis (CA) as randomized trials on GLP-1 RA have excluded patients ...

"We tried, also, other substances, like glucose and ribose," Riekeles added, "but L-serine was, for these three organisms, the most potent." However, Dirk Schulze-Makuch — a professor of ...

The authors acknowledge funding from the Foundation for Science and Technology, Portugal. The American Chemical Society (ACS) is a nonprofit organization founded in 1876 and chartered by the U.S.

Patients taking the drug, which, like HRS9531, hits GLP-1 and GIP, lost (PDF) 20.9% of their body weight across 36 weeks of treatment. By Week 88, weight loss had increased to 25.8%. In another ...