Our systematic in silico analysis identifies two interventions targeting corticotropin-releasing hormone (CRH) as effective for lowering long-term cortisol. Other targets either fail due to gland mass ...

The new structure incorporates chemical groups called sulfonates to make it compatible with water, allowing it to function in real-world water systems, like rivers or wastewater. It uses a natural ...

In this regard, chemical inducers of proximity (CIPs) offer a promising approach to precisely manipulate protein–protein interactions in live cells and in vivo. In this study, we introduce pMandi, a ...

Semaglutide mimics the action of the natural protein glucagon-like peptide 1(GLP-1), a hormone from a family of chemical messengers ... its molecules mimic the structure of GLP-1, binding to ...

Lipidated analogues of glucagon-like peptide 1 (GLP-1 ... This work provides a systematic study of the solubility, structure, oligomerization, and long-term stability of five different lipidated ...

Traditionally, blood sugar regulation has been attributed to the hormones insulin and glucagon, both produced ... the gut connected to the brain release chemical signals that bind to immune ...

Since the advent of glucagon-like peptide-1 (GLP-1) receptors (GLP-1Rs) agonists (GLP-1RAs), their potential has been extensively explored and expanded. In this review, we first summarized the ...

Based on one hypothesis, proglucagon may contain a sorting signal within its structure ... addition to glucagon, a novel proglucagon-derived peptide, proglucagon 1-61 (PG 1-61) comprised of GRPP and ...