The example is a mixture of two implementations. For example, as you can see from the latest implementation (Astropy 6.0), my_format_float() and overriding astropy.io.fits.card._format_float() are not ...

Formatted String Literals or f-Strings If your are using Python 3.6+, string f-Strings are the recommended way to format strings. From the Python 3 documentation A formatted string literal or f-string ...

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As much as I love Python, it sounds like you might be better off writing this in C. I've gone this route myself, even when dealing with way way way less data. If that is not an option, I suggest ...