Sorafenib is an oral tyrosine kinase inhibitor able to inhibit VEGF receptors 1, 2 and 3, PDGF receptors α and β, RET, Flt3, c-KIT and the RAF kinase and MAPK pathways. Over 10,000 patients have ...

Deciphera’s efforts to move it earlier in the treatment pathway have suffered some setbacks ... Daiichi Sankyo’s oral CSF-1, KIT, and FLT3 inhibitor Turalio (pexidartinib), has a black ...

In a surprising discovery, scientists have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can ...

These variants control several common biological pathways, including those governing whether and how well a cell can repair damage to its DNA, how it produces energy, and how it interacts with and ...

The Consultations on Resettlement and Complementary Pathways (CRCP), formerly the Annual Tripartite Consultations on Resettlement (ATCR) event is the most important multilateral forum for UNHCR, ...

The "Poverty, Prosperity, and Planet. Pathways Out of the Polycrisis" report evaluates progress towards these goals. It offers the first global assessment of poverty and shared prosperity ...

NEW YORK – Hemogenyx Pharmaceuticals on Monday said it has started testing the investigational anti-FLT3 CAR T-cell therapy, HG-CT-1, in patients with relapsed or refractory acute myeloid leukemia ...

Developmental and functional alterations in BTHS neutrophils are underpinned by perturbations in the unfolded protein response (UPR) signaling pathway, suggesting potential therapeutic avenues for ...

Lowering oxysterol, in both animal models and human stem cells, freed the trapped ABCA1 and restored the pathway to its healthy state. Lowering oxysterol could be a new way to prevent or treat ...