The story of one huge advance in health care shows why public investment in science is critical and why proposed cuts are ...

The National Institutes of Health focuses on nucleotides, not narratives—but both must be an essential part of its mission.

Those CCK neurons are activated by Exendin-4, a GLP-1 agonist. This suggests that one way GLP-1 agonists like Ozempic reduce appetite is by activating these specific CCK neurons. The study's ...

This work confirmed that the lizard species' unique genes produce a protein, Exendin-4, that fit the bill, mimicking GLP-1 while hanging round in the human body for far longer. A synthetic version was ...

Their research confirmed that the lizard's unique genetics produced Exendin-4, a protein that closely mirrored GLP-1 but remained active in the body much longer. This discovery eventually led to a ...

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to ...

This work confirmed that the lizard species' unique genes produce a protein, Exendin-4, that fit the bill, mimicking GLP-1 while hanging round in the human body for far longer. This isn't the only ...

Their many efforts culminated when they identified what they called exendin-4, which shared structural similarities with the human hormone GLP-1. What was even more exciting was the fact that ...