One distinct feature of transcription factors is that they have DNA-binding domains that give them the ability to bind to specific sequences of DNA called enhancer or promoter sequences.

Indeed, for NF-κB and NFAT, the DNA-binding domain is comprised of two Ig-fold regions; the N-terminal Ig-motif is responsible for sequence-specific DNA binding and the linker region that ...

By elucidating the role of the HNH nuclease domain and revealing the structural changes that occur upon DNA binding, this work not only deepens the understanding of CRISPR-Cas5-HNH but also paves ...

Now in its third year, the trial is led by The Wistar Institute in collaboration with INOVIO, AstraZeneca, and clinical investigators at the University of Pennsylvania. It is funded by the Coronavirus ...