Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin. Nuclear DNA does not appear in free linear strands; it is highly condensed and ...

RNAPII signals on histone genes also correlated with clinical grades in meningiomas, accurately predicting rapid recurrence as well as the tendency for whole-arm chromosome losses.

The findings suggest that drugs targeting histone H3 lysine-4 methylation may be effective in counteracting the effects of Polycomb mutations found in human diseases.

A single strand of DNA forms a chromosome, like the one displayed to the left. This chromosome is magnified (1000x). That's not nearly enough to show a single strand of DNA, which is only wide ...

Novel technology enables discovery, which could help predict tumour recurrence Researchers from the Fred Hutch Cancer Centre, ...

Human disease including cancer arises from disfunction of essential processes within a cell. One essential cellular process is the copying of the genomic DNA—the road map of cells—followed by ...

To convert a piece of cloned DNA into a centromere-containing human artificial chromosome (HAC), an array of repeated LacO sequences is incorporated into the DNA. The DNA is then transfected into ...