The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional H1 histone proteins are associated with each nucleosome to maintain the chromosome structure.

The histone, in turn, forms large loops. So the DNA is much, much longer than the chromosome it makes up. The DNA of one of a fruit fly's chromosomes, for example, would be 12 times longer than ...

To convert a piece of cloned DNA into a centromere-containing human artificial chromosome (HAC), an array of repeated ... LacO domains (1), and incorporates the specialized centromeric histone CENP-A ...

They discovered that despite relatively weak binding by an essential protein—histone variant CENP-A/Cse4—to DNA, other proteins are recruited to one specific site in the center of the chromosome ...

Novel technology enables discovery, which could help predict tumour recurrence Researchers from the Fred Hutch Cancer Centre, ...

Having found that in biomedical research, the Bird Rock resident and scientist at La Jolla’s Sanford Burnham Prebys has reached a milestone three decades in the making.

This course provides and overview of epigenetic mechanisms, including DNA methylation, histone modifications, chromosome structure, and nuclear organization. We will discuss how molecules help ...