At the heart of the kinetochore is a specialized nucleosome that contains centromere protein (CENP)-A, a histone H3 homologue. Several inner kinetochore components (cyan and purple ovals ...

The fusion protein binds to the LacO domains (1), and incorporates the specialized centromeric histone CENP-A into and along neighboring chromatin (2). In turn, the region of CENP-A-containing ...

Centromeres are defined by the presence of a specialized histone called CENP-A that’s critical for connecting to spindles. But how CENP-A is initially recruited is not entirely clear. Centromeres tend ...

virginiana and F. chiloensis. However, the differences in centromere characteristics and evolutionary patterns between wild and cultivated octoploids have remained poorly understood. In a study ...

They analyzed how centromere-specific histone 3 (CENH3) influences the targeting and insertion of these elements, and explored the role of retrotransposons in centromere dynamics. Centromeres ...

Researchers propose a two-step regulatory mechanism for non-Rabl configurations of centromeres in the nucleus. Centromeres are chromosomal domains that link pairs of sister chromatids together during ...