At the heart of the kinetochore is a specialized nucleosome that contains centromere protein (CENP)-A, a histone H3 homologue. Several inner kinetochore components (cyan and purple ovals ...

The fusion protein binds to the LacO domains (1), and incorporates the specialized centromeric histone CENP-A into and along neighboring chromatin (2). In turn, the region of CENP-A-containing ...

Michael Lampson, PhD is a cell biologist at the University of Pennsylvania. His research group focuses on cell division, centromere function in the germline, and the cell biology of meiotic drive.

They analyzed how centromere-specific histone 3 (CENH3) influences the targeting and insertion of these elements, and explored the role of retrotransposons in centromere dynamics. Centromeres ...

Researchers propose a two-step regulatory mechanism for non-Rabl configurations of centromeres in the nucleus. Centromeres are chromosomal domains that link pairs of sister chromatids together during ...