Macrophages are involved in all stages of HS genesis through phenotypic changes. M1-type macrophages primarily function in the early inflammatory phase by secreting pro-inflammatory factors, while ...

Furthermore, IRF5 mRNA and protein levels have been reported to be higher among monocytes and colonic macrophages in IBD patients than in healthy controls, indicating that it plays a role in disease ...

Here we show that SARS-CoV-2 mRNA vaccination significantly establishes histone H3 lysine 27 acetylation (H3K27ac) at promoters of human monocyte-derived macrophages, suggesting epigenetic memory.