Mapping gene activity in mechanically stressed bones reveals potential treatment pathways
Bone does not just grow in any which way—rather, the bone cells respond to external forces. If bones are subjected to targeted mechanical loading as they heal following a fracture, they can ...
Gene therapy and bone marrow transplant alleviate ultra-rare genetic disease symptoms
In two new papers, researchers from The Jackson Laboratory (JAX) report the successful use of two approaches—gene therapy and ...
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Gene expression analyses reveal molecular insights into bone remodeling
The structural integrity of bones has been attributed to bone remodeling—a highly regulated ... we carried out in-depth analyses of gene expression patterns of cells derived from mice with ...
Medical Xpress12d
Gene therapy may be 'one-shot stop' for rare bone disease
In a paper published in the Journal of Bone and Mineral Research, Millán's team and collaborators added additional weight to prior preclinical evidence of the safety and effectiveness of a gene ...
Science Daily12d
Gene therapy may be 'one shot stop' for rare bone disease
In mice modeled to develop late-onset HPP as adults rather than infants, the gene therapy was more effective on female mice, and in females the improvements in bone and teeth were achieved with a ...