Sclerosteosis arises from mutations in the SOST gene, causing abnormally high bone mass and skeletal overgrowth, which can ...

A landmark review in Nature Reviews Genetics dissects the rare and common genetic variants that shape human height. The paper ...

has recently been developed that acts on the cGMP signaling pathway in bone and is used to treat dwarfism in children. The parallels that our study has shown between bone growth and the formation ...

Neha Dole, an assistant  professor in the departments of Physiology and Cell Biology, Orthopaedic Surgery and Pediatrics at the University of Arkansas for Medical Sciences, will speak at 12:55 p.m.

The Wnt/β-catenin signaling pathway plays an important role in bone formation. Signaling is initiated by the binding of Wnt to a Frizzled receptor as well as a low-density lipoprotein receptor ...

Changes in your skin texture might be warning signs of internal health problems long before other symptoms show up.

Estrogen functions through binding of two different estrogen receptors (ESRs), ESR1 and ESR2. Estrogen plays an important role in bone biology, best illustrated by three points of observations ...

the team began using live mice to see if reducing plasma in the lungs slowed disease formation. This work demonstrated that blocking signaling pathways reduced plasma cell accumulation and ...

Studies suggest that by acting as a decoy receptor for myostatin—a protein believed to inhibit muscular tissue development—ACE-031 may offer novel avenues for research into wasting disorders that ...

The researchers discovered that disease-scarred lung tissue abounds in plasma cells – specialized immune cells that typically reside in bone marrow ... slowed disease formation. This work demonstrated ...

Sclerosteosis is a rare genetic disorder that causes excessive bone growth, leading to life-altering complications, including hearing loss and facial paralysis.