Most ELYSAs are also positive for an autophagy regulator, LC3 ... To investigate how the oocyte controls activation of endosome and lysosome activity, Satouh et al. used live imaging techniques to ...

First, the released mtDNA can bind to TLR9 on the surface of erythrocytes to induce an immune response or bind to TLR9 in the endosome, which promotes the ... through different pathways and can ...

Within the acidic confines of the endosome, iron is liberated and reduced to its ferrous ... establishing a direct link among ferroptosis and autophagy (Hou et al., 2016). Ferritinophagy is further ...

Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

This is the metadata section. Skip to content viewer section. Bcl2-associated athanogene-1 protein (Bag1) acts as a co-chaperone of heat shock protein 70 and heat shock cognate 70 and regulates ...

During starvation-induced autophagy, ATG2A undergoes depalmitoylation as the balance between ZDHHC11-mediated palmitoylation and APT1-mediated depalmitoylation. Inhibition of ATG2A depalmitoylation ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Type I Interferonopathy-associated variants of ...

This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...

School of Energy and Environment and State Key Laboratory of Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong, China Research Centre for the Oceans and Human Health, City University ...

Background Schaaf-Yang syndrome (SYS) is caused by truncating mutations in MAGEL2, mapping to the Prader-Willi region (15q11-q13), with an observed phenotype partially overlapping that of Prader-Willi ...