More information: Bin Xie et al, Outside-in engineering of cadherin endocytosis using a conformation strengthening antibody, Nature Communications (2025). DOI: 10.1038/s41467-025-56478-6 Provided ...

Assessment of cadherin-11 as a therapeutic target was also performed in mice with established arthritis, and administration of a monoclonal antibody towards cadherin-11 ameliorated the arthritis.

The antibody designated E4G10 was exploited to bind monomeric VE-cadherin rather than the homodimeric form, thus, conferring specificity for targeting angiogenic vessels with poor junctions rather ...